Napoli want a victory to remain high of the Serie A desk with Romelu Lukaku, Scott McTominay and Khvicha Kvaratskhelia, however Lazio have related ambitions with Taty Castellanos and Matteo Guendouzi.
It kicks off on the at 19.45 GMT.
With Atalanta registering a ninth consecutive victory, La Dea are quickly in high spot and solely a win right here would permit Antonio Conte to recapture the management.
Curiously, Napoli already confronted Lazio within the Coppa Italia Spherical of 16 on Thursday and had been crushed 3-1 on the Stadio Olimpico by a Tijjani Noslin hat-trick.
Nonetheless, that could be a completely completely different beginning XI to tonight, the place solely Pasquale Mazzocchi is out injured.
Lukaku, Kvaratskhelia and Matteo Politano had been all rested midweek and return right here with McTominay and Stanislav Lobotka in midfield.
Lazio rotated too within the Coppa Italia, albeit not fairly in such excessive trend, and noticed their run of 5 consecutive Serie A victories ended by a 3-1 loss at Parma.
Nicolò Rovella is suspended with Matias Vecino injured, however Nuno Tavares and Luca Pellegrini are again within the squad.
Guendouzi pulls the midfield strings behind Gustav Isaksen, Boulaye Dia, Mattia Zaccagni and Castellanos.
Napoli vs. Lazio line-ups
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno, Olivera; Anguissa, Lobotka, McTominay; Politano, Lukaku, Kvaratskhelia
Lazio: Provedel; Marusic, Gila, Romagnoli, Nuno Tavares; Guendouzi, Dele-Bashiru; Isaksen, Dia, Zaccagni; Castellanos
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